Spread your disease across all 21 unique regions to infect the world.
Avoid detection from region governments that will attempt to stop the progress of your disease.
Take advantage of natural disasters such as hurricanes and earthquakes to help spread your disease faster.
Use region services such as public transit and schools to spread your disease.
Contaminate region water plants to infect people faster than usual.
Use planes and boats to your advantage and spread your disease to distant regions.